Dr. Jordan et al., Pyogenic granuloma following oculoplastic procedures: An imbalance in angiogenesis regulation?, CAN J OPHTH, 36(5), 2001, pp. 260-268
Citations number
36
Categorie Soggetti
Optalmology
Journal title
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
Background: Pyogenic granuloma is a vasoproliferative inflammatory response
composed of granulation tissue. The pathogenesis is not entirely clear. We
describe a series of patients with pyogenic granulomas occurring following
common oculoplastic procedures and propose a common etiology.
Methods: Sixteen cases of pyogenic granuloma that occurred after various oc
uloplastic procedures from 1991 to 2000 were collected from the files of tw
o oculoplastic surgeons.
Results: Pyogenic granulomas were found to occur at surgical and nonsurgica
l sites associated with tissue irritation or inflammation or both.
Interpretation: Capillaries are a predominant component of wound healing an
d pyogenic granulomas. The growth and development of new capillaries follow
s an orderly sequence of events that is highly regulated by a variety of an
giogenic factors. We postulate an imbalance in angiogenesis regulation as t
he common pathway for pyogenic granuloma development.