Synthesis and in vitro cytotoxic evaluation of new derivatives of pyrido[1,2-a]benzimidazolic ring system: The pyrido[1 ',2 ': 1,2]imidazo[4,5-h]quinazolines

Access to the original series of pyrido[1 ' ,2 ' :1,2]imidazo[4,5-h]quinazo line was developed from a 1,3-dicarbonyl unit with some "N-C-N" bisnucleoph ilic reagents and the derivatives obtained were evaluated for in vitro cyto toxic activities against HL60 and A2780 cells. All compounds exhibited cyto toxic activities on resistant cell lines (MDR+; HL60R and A2780R) with no r esistance phenomena.