Some transition metal complexes with naproxen

Several transition metal complexes Of D-naproxen (HL) have been synthesized . Most of these complexes formed by the divalent metal ions have a 2:1 (lig and:metal) mole ratio and the carboxylate group of HL functions as a bridgi ng ligand. Ni(H) and Cr(III) complexes exhibit a special composition and st ructure which possesses a free ligand coordinated to and bonded via hydroge n bonds, respectively. The inflammatory models by formaldehyde-induced rat paw edema and croton oil-induced mouse ear edema were used to examine the a ntiinflammatory action of the Cu(II) complex, which enhanced the antiinflam matory activity relative to the free ligand. The pharmaceutical synergy res ulting from the coordination effect is discussed.