New synthetic method of ciprofloxacin

Authors
Chen, YQ Dai, LY
Citation
Yq. Chen et Ly. Dai, New synthetic method of ciprofloxacin, CHIN J CH E, 9(3), 2001, pp. 310-313
Citations number
7
Categorie Soggetti
Chemical Engineering
Journal title
CHINESE JOURNAL OF CHEMICAL ENGINEERING
ISSN journal
10049541 → ACNP
Volume
9
Issue
3
Year of publication
2001
Pages
310 - 313
Database
ISI
SICI code
1004-9541(200108)9:3<310:NSMOC>2.0.ZU;2-#
Abstract
A new synthetic method of ciprofloxacin is started with 2,4-dichloro-5-fluo roacetophenone, via oxalylation, ethoxymethylenation, amination, cyclizatio n, hydrolysis, decarbonylation and piperazination. The reaction temperature is moderate and the operation is easily controlled. Additional four new co mpounds are prepared by the method.