Chest pain is commonly caused by musculoskeletal chest wall disorders. Tiet
ze's syndrome is a relatively rare cause of chest wall pain characterised b
y non-suppurative, painful swelling of the upper costal cartilages. The dia
gnosis should be based on these classic clinical features after excluding o
ther potential causes of pain. A patient who was diagnosed with Tietze's sy
ndrome but was found to have squamous cell carcinoma of the mediastinum wit
h unknown primary site invading the sternum and anterior chest wall is pres
ented for discussion.