Properties of instrumental variable estimators are sensitive to the choice
of valid instruments, even in large cross-section applications. In this pap
er we address this problem by deriving simple mean-square error criteria th
at can be minimized to choose the instrument set. We develop these criteria
for two-stage least squares (2SLS), limited information maximum likelihood
(LIML), and a bias adjusted version of 2SLS (B2SLS). We give a theoretical
derivation of the mean-square error and show optimality. In Monte Carlo ex
periments we find that the instrument choice generally yields an improvemen
t in performance. Also, in the Angrist and Krueger (1991) returns to educat
ion application, when the instrument set is chosen in the way we consider,
it turns out that both 2SLS and LIML give similar (large) returns to educat
ion.