Epileptic seizures after treatment with thiocolchicoside

Purpose: To report the occurrence of epileptic seizures in humans. closely related to the use of the centrally acting muscle relaxant thiocolchicoside . Methods: Description of three case histories. Results: Two patients, affected with complex-partial seizures. sometimes se condarily generalized, receiving antiepileptic therapy, were seizure free f or 7 and 9 years, respectively. They had the reappearance of tonic-clonic s eizures few days after the continued use of thiocolchicoside, at a cumulati ve dose of the drug of 52 mg and 76 mg. respectively. The third patient was brain damaged and without a history of seizures. He had a sudden. convulsi ve seizure a few minutes after 4 mg intramuscular thiocolchicoside. Conclusions: Our case histories indicate that thiocolchicoside has a powerf ul epileptogenic activity. This drug should be avoided in patients with epi lepsy or acute brain injury and possible disruption of the blood-brain barr ier.