The enactment of the Bayh-Dole Act in 1980 by the U.S. Congress allowed uni
versities and small businesses to own patents on research which had been fe
derally-sponsored. This has revolutionized the relationship between academi
a and industry. The legislation allowed universities to license their paten
ts to industry, exclusively or non-exclusively. Royalties, received by the
universities for such licensing, are used for further research and educatio
n as well as for rewarding the inventor(s). The intellectual property (the
patent) is held by the university and licensed to new or existing companies
. Intellectual property is also a key component in research collaborations
between universities and companies. Although the interests of the academic
and the industrial partner are very different, successful collaboration has
been possible when both parties respect each other's interests and ease th
e tension around intellectual property considerations. The thorny issue of
publication from such collaborations is resolved by allowing the company 30
-60 days to examine the manuscript and determine whether patentable inventi
ons are present. Within this period, the patent is filed and the academics
are then able to submit the manuscript for publication. The industrial part
ner is offered the following alternatives: (i) a non-exclusive license to t
he technology at zero or nominal royalty; (ii) a royalty-bearing exclusive
license; or (iii) a waiver of rights for a share of the university's licens
ing revenues (the last being offered by only a few universities). The unive
rsity charges the company the same overhead rate that it charges the federa
l government on grants. Successful interactions between academia and indust
ry rely on interpersonal (= interscientist) relations on both sides; freque
nt contact is recommended. The royalty income of leading universities repre
sents, on the average, about 0.5 to 2 % of the annual research budget. In a
few cases, some successful universities have obtained major revenues from
one or two very successful licenses. University licensing has led to the es
tablishment of an impressive number of new companies. M.I.T. is currently g
ranting 80 to 100 licenses per year to its technology, and spinning off 10
to 20 new companies per year; since 1987, 202 new companies have been found
ed. Nationally, over 2000 new companies have been established around univer
sity technology licenses.