M. Bosnjak et S. Bogdan, Introduction to the theoretical fundamentals for increasing the probability of heterologous contacts between biological particles, FOOD TECH B, 39(3), 2001, pp. 183-196
An introduction to the theoretical fundamentals referring to the contacts a
ppearing between biological particles is given. Factors affecting the proba
ble frequency of different contacts were analysed with reference to their e
ffects on possible heterologous recombinations which could lead to the appe
arance and the growth of microbial cells having new properties and being ca
pable to produce new biologically active compounds. Effects of the differen
ces in bioparticle morphology and cultivation methods are discussed. Kineti
cs of the process events in hypothetical mixed culture of the two parent mi
crobial strains were studied applying computer simulation. This was perform
ed on the basis of mathematical model developed for such a purpose. Results
of computer simulation suggest that the applied mathematical model appears
to be the adequate one for explaining the growth kinetics of a new strain
and its parent strains. The kinetics of other events can also be well expla
ined. In discussing the relevance of particular parameters a special emphas
is was given to the biological character of microbial cells. The ability of
microbial cells to adapt their properties and behaviour in accordance to t
he properties of their environment is a factor of essential importance.