Introduction to the theoretical fundamentals for increasing the probability of heterologous contacts between biological particles

An introduction to the theoretical fundamentals referring to the contacts a ppearing between biological particles is given. Factors affecting the proba ble frequency of different contacts were analysed with reference to their e ffects on possible heterologous recombinations which could lead to the appe arance and the growth of microbial cells having new properties and being ca pable to produce new biologically active compounds. Effects of the differen ces in bioparticle morphology and cultivation methods are discussed. Kineti cs of the process events in hypothetical mixed culture of the two parent mi crobial strains were studied applying computer simulation. This was perform ed on the basis of mathematical model developed for such a purpose. Results of computer simulation suggest that the applied mathematical model appears to be the adequate one for explaining the growth kinetics of a new strain and its parent strains. The kinetics of other events can also be well expla ined. In discussing the relevance of particular parameters a special emphas is was given to the biological character of microbial cells. The ability of microbial cells to adapt their properties and behaviour in accordance to t he properties of their environment is a factor of essential importance.