The effect of spatial variability of the atmospheric CO2 distribution on te
mperature and water vapor retrievals from high spectral resolution observat
ions of infrared emission is estimated by performing 4 different retrieval
experiments. Using a global mean CO2 value, as currently routinely used, in
troduces errors in the retrieved temperature profile of up to 0.85 K compar
ed to a retrieval in which the CO2 profile is known exactly. Including CO2
in the retrieval vector reduces these errors to 0.3 K. A more practical alt
ernative, especially for data assimilation, is to use a monthly mean zonal
mean CO2 value, which produces errors of up to 0.35 K in the temperature pr
ofile.