Mouse models of metastatic pancreatic adenocarcinoma

Pancreatic adenocarcinoma is a deadly disease. Its etiology is unknown, and metastatic disease kills the majority of patients who have it. Effective p revention is clearly the ultimate goal for eradicating this disease provide d that the effects of environmental and genetic elements on pancreatic canc er development are fully understood. Currently, it appears that the control of pancreatic cancer metastasis is of immediate urgency. Fulfillment of th is difficult task relies on knowledge of the cellular and molecular biology of metastasis. The use of relevant animal models will help define each asp ect of this complicated process.