Dynamic curvature strongly affects wall shear rates in a coronary artery bifurcation model

This study was motivated by the need for a better understanding of coronary artery blood flow patterns and their possible role in atherosclerosis form ation. Of particular interest in this study was the effects of the dynamic deformation due to myocardial contraction on wall shear rate patterns in th e coronary arteries. A better understanding of these effects on wall shear rate in a bifurcation geometry and an evaluation of the importance of these effects was desired, A three-dimensional computer model of a bifurcation l ying on the surface of a sphere with time-varying radius of curvature was e mployed to simulate the motion and deformation of the arteries. The results indicated low mean shear rates along the myocardial wall and very high she ar rate variations (over 100% of the static mean shear rate) along the oute r wall. The results obtained using a quasi-static analysis were found to un derestimate the dynamic wall shear rate variation along the myocardial and outer walls. It was concluded that dynamic geometry effects are important i n determining sites of low mean and oscillating wall shear that have been a ssociated with atherogenesis in curved, bifurcating arteries. (C) 2001 Else vier Science Ltd. All rights reserved.