HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF SODIUM CROMOGLYCATE

A simple and precise liquid chromatographic method was developed for t he estimation of sodium cromoglycate (SC) in pharmaceuticals. The drug was chromatographed on a reverse phase C18 column. The eluants were m onitored at a wavelength of 325 nm utilizing a mixture (80:20) of solu tion A: 0.025 M I-octane sulfonic acid sodium salt in acetic acid (1:1 00), and solution B: methanol, acetonitrile (3:2). Solution concentrat ions were measured on a weight basis to avoid the use of an internal s tandard. The method uns statistically validated for its linearity, acc uracy, precision, selectivity, limit of detection and limit of quantit ation. Due to its simplicity and accuracy, the authors believe that th e method can be used for routine quality control analysis. It does not require any specific sample preparation except for the use of a colum n guard before the analytical column and a suitable prefilter attached to the syringe prior to injection.