Association of the T102C polymorphism of 5-HT2A receptor gene with aura inmigraine

Objective: To find out the significance of the 5-HT2A receptor gene polymor phism in migraine. Study design: A PCR study in which 61 migraineurs and 44 healthy controls were included. Methods: The T102C polymorphism of the 5-H T2A receptor gene was studied. The results of the migraineurs and controls were compared. The relationship between the gene polymorphism and aura was also assessed. Results: The representations of the 5-HT2A genotypes were si milar in migraineurs and controls ( p > 0.05) as well as in the male and fe male migraineurs (p > 0.05). The family history of migraine did not associa te with 5-HT2A receptor gene polymorphism (p > 0.05). There was a significa nt relationship between the presence of C/C genotype and migraine with aura (p = 0.02) while C/T and T/T genotypes were over represented in the patien ts with migraine without aura (p < 0.01). Conclusion: The T102C polymorphis m of the 5-HT2A receptor gene is not directly related to the increased risk of migraine. The associations between the genotypes of this gene and aura may suggest that 5-HT2A receptor gene polymorphism may be involved in deter mining the subtypes of or accompanying symptoms in the migraine disease. (C ) 2001 Published by Elsevier Science B.V.