The spectrophotometric simultaneous determination of amitryptyline and chlorpromazine hydrochlorides in their binary mixtures

The application of the Vierordt's method and derivative spectrophotometry f or simultaneous determination of amitryptyline (AMT) and chlorpromazine (CP M) hydrochlorides in their binary mixtures are presented. Both methods allo w to determine the components without their isolation. By derivative spectr ophotometry, amitryptyline hydrochloride can be determined in the range of 2-15 mug/ml and chlorpromazine hydrochloride between 2-53 mug/ml. The accep table error was obtained when the ratio analyte:second component ranges fro m 3:1 to 50:1 for amitryptyline and 0.1:1-0.8:1 for chlorpromazine. The Vie rordt's method can be applied for resolution of the studied mixture when th e ratio analyte: second component is in the 3:1-45:1 and 11:1-57:1 range fo r amitryptyline and chlorpromazine, respectively.