Angiogenesis in acute and chronic leukemias

Angiogenesis plays a key role in the growth of solid tumors. More recently, accumulating evidence has linked angiogenesis to the pathophysiology of le ukemias. Different investigators have shown evidence of increased angiogene sis in the bone marrows of patients with acute and chronic leukemias. Eleva ted levels of angiogenic factors have also been reported in leukemic patien ts. A potential role for VEGF as an autocrine growth factor in AML has been suggested. Studies on the role of angiogenesis and VEGF as prognostic fact ors in leukemia require confirmation. The role of angiogenesis inhibitors i n the treatment of leukemia is currently under investigation.