Multiple granulocytic sarcomas in acute myeloblastic leukemia with simultaneous occurrence of t(8 : 21) and trisomy 8

This report describes a rare case of multiple intracranial, extradural chlo romas. A five year old African American male presented with headache, fever , and vomiting. The peripheral blood smear showed myeloblasts with Auer rod s. The CTscan of the brain showed three intracranial, epidural lesions as w ell as soft tissue masses in the retroorbital region and sphenoid sinuses. CTscan of the chest showed two paraspinal epidural thoracic masses. Patholo gy of the epidural intracranial mass revealed a granulocytic sarcoma. Cytog enetic analysis showed simultaneous occurrence of t (8;21) and trisomy 8. F ollowing induction therapy, he is now in complete remission.