Effects of AH-9700, (+)-pentazocine, DTG and oxybutynin on micturition in anesthetized rats with acetone-induced cystitis

We investigated the effects of AH-9700 (1-[2-(3,4-dihydro-6,7-dimethyl-2-na phthalenyl)ethyl] pyrrolidine fumarate; a novel sigma receptor ligand), (+) -pentazocine and 1,3-di-o-tolylguanidine (DTG) (two typical sigma receptor ligands), and oxybutynin (a currently used anti-pollakiuria drug) on cystom etrograms in anesthetized rats with 30% acetone-induced cystitis. Compared to sham-treated rats, acetone-treated cystitis models exhibited an increase in urinary frequency during continuous filling cystometry. Intravenous adm inistration of AH-9700 (1-5 mg/kg), (+)-pentazocine or DTG to the rats with cystitis dose-dependently prolonged micturition intervals and increased th e micturition threshold pressure. Oxybutynin (1 mg/kg, i.v.) also extended micturition intervals, but decreased the micturition pressure. These result s indicate that AH-9700, (+)-pentazocine and DTG improve abnormal frequent urination caused by acetone-induced cystitis in a manner different from tha t of oxybutynin. (C) 2001 Elsevier Science Inc. All rights reserved.