ACCORD-ADEQUATE: an improved technique for the acquisition of inverse-detected INADEQUATE data

A new approach for the acquisition of IH-detected INADEQUATE-type data is p resented. This method uses a decremented variable delay for the evolution o f (1)J((C,C)) couplings. It is demonstrated that this variation of the 1,1- ADEQUATE experiment provides superior performance when compared with the no rmal static-optimized 1,1-ADEQUATE experiment. This improvement is manifest ed in both the number and quality of correlations present in the processed data. The technique was validated using the model compound ethyl trans-crot onate and its utility was demonstrated utilizing the structurally unique ma rine natural product jamaicamide A. Copyright (C) 2001 John Wiley & Sons, L td.