Cerebral T-1 rho relaxation time increases immediately upon global ischemia in the rat independently of blood glucose and anoxic depolarization

Citation
Mi. Kettunen et al., Cerebral T-1 rho relaxation time increases immediately upon global ischemia in the rat independently of blood glucose and anoxic depolarization, MAGN RES M, 46(3), 2001, pp. 565-572
Citations number
40
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
MAGNETIC RESONANCE IN MEDICINE
ISSN journal
07403194 → ACNP
Volume
46
Issue
3
Year of publication
2001
Pages
565 - 572
Database
ISI
SICI code
0740-3194(200109)46:3<565:CTRRTI>2.0.ZU;2-Z
Abstract
Time-dependent changes of T-1 in the rotating frame (T-1 rho), diffusion, T -2, and magnetization transfer contrast on cardiac arrest-induced global is chemia in rat were investigated. T-1 rho, a acquired with spin lock amplitu des >0.6 G, started to increase 10-20 sec after cardiac arrest followed by an increase within 3-4 min to a level that was 6-8% greater than in normal brain. The ischemic T-1 rho response coincided with the drop of water diffu sion coefficient in normoglycemic animals. However, unlike the rate of diff usion, the kinetics of T-1 rho were not affected by either preischemic hypo glycemia or hyperglycemia. Similar to diffusion, the kinetics of anoxic dep olarization were dependent on preischemic blood glucose levels. Ischemia ca used a reduction in the Hahn spin echo T-2 as a result of blood oxygenation level-dependent (BOLD) effect; maximal negative BOLD seen by 40 sec. In th e animals injected with an ironoxide particle contrast agent, AMI-227, prio r to the insult, both T-1 rho and T-2 immediately increased in concert on i nduction of ischemia. In contrast to the T-1 rho and diffusion changes, a m uch slower change in magnetization transfer contrast was evident over the f irst 20 min of ischemia. These data demonstrate that T-1 rho immediately in creases following ischemia and that the pathophysiological mechanisms affec ting this relaxation time may not directly involve magnetization transfer. The mechanisms prolonging T-1 rho differ from those affecting water diffusi on with respect to their sensitivities to glucose and are apparently indepe ndent of membrane depolarization. (C) 2001 Wiley-Liss, Inc.