ENGINEERING NOVEL PROTEINS BY TRANSFER OF ACTIVE-SITES TO NATURAL SCAFFOLDS

Authors
VITA C
Citation
C. Vita, ENGINEERING NOVEL PROTEINS BY TRANSFER OF ACTIVE-SITES TO NATURAL SCAFFOLDS, Current opinion in biotechnology, 8(4), 1997, pp. 429-434
Citations number
36
Categorie Soggetti
Biothechnology & Applied Migrobiology","Biochemical Research Methods
Journal title
Current opinion in biotechnology → ACNP
ISSN journal
09581669
Volume
8
Issue
4
Year of publication
1997
Pages
429 - 434
Database
ISI
SICI code
0958-1669(1997)8:4<429:ENPBTO>2.0.ZU;2-Y
Abstract
Novel functional proteins have been generated by the transfer of activ e sites to structurally homologous proteins and to new structural cont exts. The most successful examples of these approaches succeeded in pr oviding effective new tools in biochemistry and protein chemistry and in suggesting new models in drug design.