Major mRNP proteins in the structural organization and function of mRNA ineukaryotic cells

Authors
Ovchinnikov, LP Skabkin, MA Ruzanov, PV Evdokimova, VM
Citation
Lp. Ovchinnikov et al., Major mRNP proteins in the structural organization and function of mRNA ineukaryotic cells, MOL BIOL, 35(4), 2001, pp. 462-471
Citations number
105
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
35
Issue
4
Year of publication
2001
Pages
462 - 471
Database
ISI
SICI code
0026-8933(200107/08)35:4<462:MMPITS>2.0.ZU;2-J
Abstract
The properties of two universal major proteins of cytoplasmic mRNP, p50 and the poly(A)-binding protein (PABP), are summarized. Their roles in formati on of polyribosomal and free inactive mRNP are considered, with the focus o n the authors' studies of p50. The parts these mRNP proteins play in transl ation regulation, stability, and localization of mRNA are described, and th e possible mechanisms of their function are discussed.