Structure and functions of the prokaryotic elongation factor G

Structural and functional data on elongation factor G (EF-G) are reviewed w ith regard to nucleotide exchange, GTP hydrolysis, mechanism of action of f usidic acid, and functional roles of the EF-G structural domains in translo cation. Biochemical data are correlated with structural dynamics of the EF- G molecule on interaction with various ligands. Data on EF-Tu are also cons idered, as EF-G and EF-Tu share certain structural and functional features.