Emergence of input specificity of LTP during development of retinotectal connections in vivo

Citation
Hzw. Tao et al., Emergence of input specificity of LTP during development of retinotectal connections in vivo, NEURON, 31(4), 2001, pp. 569-580
Citations number
54
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEURON
ISSN journal
08966273 → ACNP
Volume
31
Issue
4
Year of publication
2001
Pages
569 - 580
Database
ISI
SICI code
0896-6273(20010830)31:4<569:EOISOL>2.0.ZU;2-O
Abstract
Input specificity of activity-induced synaptic modification was examined in the developing Xenopus retinotectal connections. Early in development, lon g-term potentiation (LTP) induced by theta burst stimulation (TBS) at one r etinal input spreads to other unstimulated converging inputs on the same te ctal neuron. As the animal develops, LTP induced by the same TBS becomes in put specific, a change that correlates with the increased complexity of tec tal dendrites, and more restricted distribution of dendritic Ca2+ evoked by each retinal input. In contrast, LTP induced by 1 Hz correlated pre- and p ostsynaptic spiking is input specific throughout the same developmental per iod. Thus, input specificity of LTP emerges with neural development and dep ends on the pattern of synaptic activity.