Energizing epithelial transport with the vacuolar H+-ATPase

Authors
Beyenbach, KW
Citation
Kw. Beyenbach, Energizing epithelial transport with the vacuolar H+-ATPase, NEWS PHYSL, 16, 2001, pp. 145-151
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
16
Year of publication
2001
Pages
145 - 151
Database
ISI
SICI code
0886-1714(200108)16:<145:EETWTV>2.0.ZU;2-7
Abstract
The Ussing model has long provided the conceptual foundation for understand ing epithelial transport mechanisms energized by the Na+-K+-ATPase. Plasma membranes may also use the vacuolar (V-type) H+-ATPase as the primary energ y source of membrane and epithelial transport. A pure electrogenic pump, th e V-type H+-ATPase energizes not only membranes it inhabits but also other transport pathways via electrical coupling.