The intrarenal endothelin system and hypertension

Authors
Abassi, ZA Ellahham, S Winaver, J Hoffman, A
Citation
Za. Abassi et al., The intrarenal endothelin system and hypertension, NEWS PHYSL, 16, 2001, pp. 152-156
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
16
Year of publication
2001
Pages
152 - 156
Database
ISI
SICI code
0886-1714(200108)16:<152:TIESAH>2.0.ZU;2-V
Abstract
The kidney is both a source of endothelin (ET) generation and an important target organ of this peptide. The highest concentrations of ET-1 in the bod y exist in the renal medulla, where it mediates natriuretic and diuretic ef fects through the ETB receptor subtype. It is proposed that aberrations in the renal ET system may lead to sodium and water retention and subsequently to the development of hypertension.