2 '-C-alkoxy and 2 '-C-aryloxy derivatives of N-(2-phosphonomethoxyethyl)purines and -pyrimidines: Synthesis and biological activity

Authors
Rejman, D Masojidkova, M De Clercq, E Rosenberg, I
Citation
D. Rejman et al., 2 '-C-alkoxy and 2 '-C-aryloxy derivatives of N-(2-phosphonomethoxyethyl)purines and -pyrimidines: Synthesis and biological activity, NUCLEOS NUC, 20(8), 2001, pp. 1497-1522
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
8
Year of publication
2001
Pages
1497 - 1522
Database
ISI
SICI code
1525-7770(2001)20:8<1497:2'A2'D>2.0.ZU;2-Q
Abstract
A series of novel, unusual type of acyclic phosphonate-based nucleotide ana logues related to well-known antivirals (PMEA and HPMPA) was synthesized us ing easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives that contribute to the understanding of structure-activity relationship wi thin the area of acyclic nucleotide analogues.