A new method for the synthesis of N-2-alkylguanosines using Mitsunobu reaction as a key step

Authors
Kozai, S Yorikane, A Maruyama, T
Citation
S. Kozai et al., A new method for the synthesis of N-2-alkylguanosines using Mitsunobu reaction as a key step, NUCLEOS NUC, 20(8), 2001, pp. 1523-1531
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
8
Year of publication
2001
Pages
1523 - 1531
Database
ISI
SICI code
1525-7770(2001)20:8<1523:ANMFTS>2.0.ZU;2-X
Abstract
Peracetylated guanosine was reacted With POCl3 to give an 2-acetamido-6-chl oro-9H-purine derivative, which was condensed with primary or secondary alc ohols to give N-2-alkylated analogues. The products were treated with merca ptoethanol in the presence of sodium methoxide to afford N-2-alkylguanosine s.