Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by alpha-boranophosphate substitution

Authors
Schneider, B Meyer, P Sarfati, S Mulard, L Guerreiro, C Boretto, J Janin, J Veron, M Deville-Bonne, D Canard, B
Citation
B. Schneider et al., Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by alpha-boranophosphate substitution, NUCLEOS NUC, 20(4-7), 2001, pp. 297-306
Citations number
14
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
297 - 306
Database
ISI
SICI code
1525-7770(2001)20:4-7<297:AOATNA>2.0.ZU;2-T
Abstract
Nucleoside activation by nucleoside diphosphate kinase and inhibition of HI V-1 reverse transcriptase were studied comparatively for a new class of nuc leoside analogs with a borano (BH3-) or a thio (SH) group on the ce-phospha te. Both the alpha -Rp-borano derivatives of AZT and d4T improved phosphory lation by NDP kinase, inhibition of reverse transcription as well as stabil ity of alpha -borano monophosphate derivatives in terminated viral DNA chai n.