Synthesis, hydrolysis and anti-EBV activity of a series of 3 '-modified cycloSal-BVDUMP pronucleotides

Authors
Meier, C Lomp, A Meerbach, A Wutzler, P
Citation
C. Meier et al., Synthesis, hydrolysis and anti-EBV activity of a series of 3 '-modified cycloSal-BVDUMP pronucleotides, NUCLEOS NUC, 20(4-7), 2001, pp. 307-314
Citations number
25
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
307 - 314
Database
ISI
SICI code
1525-7770(2001)20:4-7<307:SHAAAO>2.0.ZU;2-C
Abstract
A series of cycloSal-BVDUMP phosphate triesters has been prepared. The prot otype compound was 3-methyl-cycloSal-BVDUMP 2. Furthermore, a series of 3'- O-acyl-modified derivatives having carboxylic acids with different lipophil icity or a L-configurated alpha -amino acid (phenylalanine) was prepared. T he hydrolysis properties in phosphate buffer PBS as well as in PBS containi ng pig liver esterase (PLE) will be described. Finally, the biological acti vity against EBV has been determined.