Understanding the mode of action of L-nucleosides as antiviral agents: A molecular modeling approach

Authors
Lee, K Chong, YH Chu, CK
Citation
K. Lee et al., Understanding the mode of action of L-nucleosides as antiviral agents: A molecular modeling approach, NUCLEOS NUC, 20(4-7), 2001, pp. 385-388
Citations number
16
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
385 - 388
Database
ISI
SICI code
1525-7770(2001)20:4-7<385:UTMOAO>2.0.ZU;2-9
Abstract
Computer modeling studies have been performed on the several pairs Of D- an d L-nucleoside inhibitors with the HIV-1 RT model. Additionally, clinically important M184V mutation, which confers the viral resistance against 3TC a nd FTC, were studied by the same modeling system.