DNA triple-helix formation at pyrimidine-purine inversion sites

Authors
Parel, SP Marfurt, J Leumann, CJ
Citation
Sp. Parel et al., DNA triple-helix formation at pyrimidine-purine inversion sites, NUCLEOS NUC, 20(4-7), 2001, pp. 411-417
Citations number
23
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
411 - 417
Database
ISI
SICI code
1525-7770(2001)20:4-7<411:DTFAPI>2.0.ZU;2-S
Abstract
A systematic investigation of a series of triplex forming oligonucleotides (TFOs) containing alpha-, and beta- thymidine, alpha- and beta -N7-hypoxant hine, and alpha- and beta- N7 and N9 aminopurine nucleosides. designed to b ind to T-A inversion sites in DNA target sequences was performed. Data obta ined from gel mobility assays indicate that T-A recognition in the antipara llel triple-helical binding motif is possible if the nucleoside alpha N9-am inopurine is used opposite to the inversion site in the TFO.