Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs deliveredin pH-sensitive liposomes

Authors
Duzgunes, N Simoes, S Slepushkin, V Pretzer, E Rossi, JJ De Clercq, E Antao, VP Collins, ML de Lima, MCP
Citation
N. Duzgunes et al., Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs deliveredin pH-sensitive liposomes, NUCLEOS NUC, 20(4-7), 2001, pp. 515-523
Citations number
39
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
515 - 523
Database
ISI
SICI code
1525-7770(2001)20:4-7<515:EIOHRI>2.0.ZU;2-N
Abstract
An antisense oligodeoxynucleotide against the human immunodeficiency virus type 1 (HIV-1) Rev response element, a ribozyme complementary to the HIV-1 5'-LTR, and the reverse transcriptase inhibitors 9-(2-phosphonylmethoxyethy l) adenine (PMEA) and(R)-9-(2-phosphonylmethoxypropyl)-adenine (PMPA) inhib ited virus replication in monocyte-derived macrophages more effectively whe n delivered in pH-sensitive liposomes compared to the free drugs.