Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs deliveredin pH-sensitive liposomes
N. Duzgunes et al., Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs deliveredin pH-sensitive liposomes, NUCLEOS NUC, 20(4-7), 2001, pp. 515-523
An antisense oligodeoxynucleotide against the human immunodeficiency virus
type 1 (HIV-1) Rev response element, a ribozyme complementary to the HIV-1
5'-LTR, and the reverse transcriptase inhibitors 9-(2-phosphonylmethoxyethy
l) adenine (PMEA) and(R)-9-(2-phosphonylmethoxypropyl)-adenine (PMPA) inhib
ited virus replication in monocyte-derived macrophages more effectively whe
n delivered in pH-sensitive liposomes compared to the free drugs.