Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuranskeleton with long alkyl chains

Authors
Sasaki, S Shibata, T Torigoe, H Shibata, Y Maeda, M
Citation
S. Sasaki et al., Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuranskeleton with long alkyl chains, NUCLEOS NUC, 20(4-7), 2001, pp. 551-558
Citations number
15
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
551 - 558
Database
ISI
SICI code
1525-7770(2001)20:4-7<551:NCODBM>2.0.ZU;2-3
Abstract
Small molecules with DNA-binding affinity within the minor groove have beco me of great interest. In this paper, new DNA binding molecules; diamino-bis tetrahydrofuran (bisTHF) and diamino-bisfuran are reported. The bisTHF liga nd with RR configuration at the amino groups and C8 alkyl chains (RR8) stab ilized GC-rich duplex. In contrast, bisfuran compounds stabilized AT-rich d uplex. The binding affinity of RR8 with 12 mer duplex DNA was determined by isothermal titration calorimetry to be 3.3 x 10(8) M-1.