Synthesis and antiproliferative activity of some 4 '-C-hydroxymethy-alpha-and -beta-D-arabino-pentofuranosyl pyrimidine nucleosides

Authors
Griffon, JF Montgomery, JA Secrist, JA
Citation
Jf. Griffon et al., Synthesis and antiproliferative activity of some 4 '-C-hydroxymethy-alpha-and -beta-D-arabino-pentofuranosyl pyrimidine nucleosides, NUCLEOS NUC, 20(4-7), 2001, pp. 649-652
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
649 - 652
Database
ISI
SICI code
1525-7770(2001)20:4-7<649:SAAAOS>2.0.ZU;2-R
Abstract
A suitably protected 4-C-hydroxymethyl-arabino-pentofuranose was prepared a nd condensed with the following nucleobases: uracil, 5-fluorouracil and thy mine. The corresponding cytosine and 5-fluorocytosine derivatives have also been obtained respectively from the uracil and 5-fluorouracil nucleosides. Separation of the anomeric mixtures followed by deprotection afforded the target compounds that were found to be non-cytotoxic to CCRF-CEM leukemia c ells.