Synthesis and in vitro evaluation of novel anti-varicella-zoster virus (VZV) nucleosides

Authors
Carangio, A McGuigan, C Cahard, D Andrei, G Snoeck, R De Clercq, E Balzarini, J
Citation
A. Carangio et al., Synthesis and in vitro evaluation of novel anti-varicella-zoster virus (VZV) nucleosides, NUCLEOS NUC, 20(4-7), 2001, pp. 653-656
Citations number
6
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
653 - 656
Database
ISI
SICI code
1525-7770(2001)20:4-7<653:SAIVEO>2.0.ZU;2-I
Abstract
A series of alkyl-aryl, -phenoxy, and -thiophenoxy bicyclic furo pyrimidine nucleosides have been successfully synthesised by Pd-coupling of 5-iodo-2' -deoxyuridine (IDU) with terminal alkynes, followed by in situ copper-cycli sation. Synthesised compounds (4a-i) showed an anti-VZV activity at low muM concentration, comparable to that of current treatment acyclovir.