Structure-activity relationships of APIO nucleosides as potential antiviral agents

Authors
Jeong, LS Moon, HR Hong, JH Yoo, SJ Choi, WJ Kim, HO Ahn, HS Baek, HW Chun, MW Kim, HD Kim, J Choi, JR
Citation
Ls. Jeong et al., Structure-activity relationships of APIO nucleosides as potential antiviral agents, NUCLEOS NUC, 20(4-7), 2001, pp. 657-660
Citations number
7
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
657 - 660
Database
ISI
SICI code
1525-7770(2001)20:4-7<657:SROANA>2.0.ZU;2-G
Abstract
Several types of novel apio nucleosides were synthesized starting from 1,3- dihydroxyacetone and evaluated for antiviral activity. Among compounds test ed, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Ap io dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activit y, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exh ibit any significant antiviral activity.