Synthesis and antiviral activity of D- and L-2 '-azido-2 ',3 '-dideoxy-4 '-thiopyrimidine and purine nucleosides

Authors
Jeong, LS Kim, YH Kim, HO Yoo, SJ Park, YH Yeon, SH Chun, MW Kim, HD
Citation
Ls. Jeong et al., Synthesis and antiviral activity of D- and L-2 '-azido-2 ',3 '-dideoxy-4 '-thiopyrimidine and purine nucleosides, NUCLEOS NUC, 20(4-7), 2001, pp. 665-668
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
665 - 668
Database
ISI
SICI code
1525-7770(2001)20:4-7<665:SAAAOD>2.0.ZU;2-X
Abstract
Novel D- and L-2'-azido-2',3'-dideoxy-4'-thionucleosides were synthesized s tarting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they w ere found to be only active against HCMV without cytotoxicity up to 100 mug /ml.