Synthesis and study of a new series of phosphoramidate derivatives as mononucleotide prodrugs

Authors
Egron, D Perigaud, C Gosselin, G Aubertin, AM Imbach, JL
Citation
D. Egron et al., Synthesis and study of a new series of phosphoramidate derivatives as mononucleotide prodrugs, NUCLEOS NUC, 20(4-7), 2001, pp. 751-754
Citations number
7
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
751 - 754
Database
ISI
SICI code
1525-7770(2001)20:4-7<751:SASOAN>2.0.ZU;2-0
Abstract
The synthesis and the study of new mononucleoside phosphoramidate diesters bearing S-acyl-2-thioethyl (SATE) groups and an alkylamino residue are repo rted. The studied compounds appear to be able to deliver the corresponding 5'-mononucleotide inside the cells, and could be considered as prototypes f or a new kind of mononucleotide prodrugs (pronucleotides).