Stacking and stability of RNA duplexes containing fluorobenzene and fluorobenzimidazole nucleosides

Authors
Parsch, J Engels, JW
Citation
J. Parsch et Jw. Engels, Stacking and stability of RNA duplexes containing fluorobenzene and fluorobenzimidazole nucleosides, NUCLEOS NUC, 20(4-7), 2001, pp. 815-818
Citations number
10
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
815 - 818
Database
ISI
SICI code
1525-7770(2001)20:4-7<815:SASORD>2.0.ZU;2-K
Abstract
Six different fluorobenzene or fluorobenzimidazole ribonucleosides and one abasic site were incorporated in oligoribonucleotides. Individual contribut ions of base stacking and solvation of the modified nucleosides could be de termined. In fluorobenzene . fluorobenzimidazole-modified base pairs a dupl ex stabilizing force was found that points to a weak F...H hydrogen bond. T he lipophilicity of the unprotected nucleosides were investigated by determ ination of 1-octanol water partition coefficients.