Oligonucleotides with isopolar phosphonate internucleotide linkage: A new perspective for antisense compounds?

Authors
Rejman, D Snasel, J Liboska, R Tocik, Z Paces, O Kralikova, S Rinnova, M Kois, P Rosenberg, I
Citation
D. Rejman et al., Oligonucleotides with isopolar phosphonate internucleotide linkage: A new perspective for antisense compounds?, NUCLEOS NUC, 20(4-7), 2001, pp. 819-823
Citations number
11
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
819 - 823
Database
ISI
SICI code
1525-7770(2001)20:4-7<819:OWIPIL>2.0.ZU;2-K
Abstract
Several types of isopolar modified oligothymidylates and oligoadenylates (1 5 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepa red. The modified oligonucleotides were subjected to the study of their hyb ridization properties, resistance against nucleases, and the ability to eli cit RNase H activity.