Antisense properties of 2 '-O-dimethylaminooxyethyl (2 '-O-DMAOE) oligonucleotides

Authors
Prakash, TP Kawasaki, AM Johnston, JF Graham, MJ Condon, TP Manoharan, M
Citation
Tp. Prakash et al., Antisense properties of 2 '-O-dimethylaminooxyethyl (2 '-O-DMAOE) oligonucleotides, NUCLEOS NUC, 20(4-7), 2001, pp. 829-832
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
829 - 832
Database
ISI
SICI code
1525-7770(2001)20:4-7<829:APO2'(>2.0.ZU;2-E
Abstract
Antisense oligonucleotides with 2'-O-{2-[N,N-dimethyl)aminooxy]ethyl} or (2 '-O-DMAOE) modification were synthesized and evaluated for nuclease resista nce and pharmacology both in vitro and in vivo. This modification exhibits very high nuclease resistance and efficacy in various biological (ICAM-1, C -raf and PKC-alpha) targets.