Cu2+-dependent DNA-cleaving activity of arenes

Authors
Koval, OA Chernolovskaya, EL Litvak, VV Vlassov, VV
Citation
Oa. Koval et al., Cu2+-dependent DNA-cleaving activity of arenes, NUCLEOS NUC, 20(4-7), 2001, pp. 851-854
Citations number
3
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
851 - 854
Database
ISI
SICI code
1525-7770(2001)20:4-7<851:CDAOA>2.0.ZU;2-N
Abstract
In the presence of Cu(II) ions, plasmid DNA is cleaved under physiological condition by different arenes at low concentrations. The cleavage was depen dent on the presence Of O-2. The DNA cleavage efficiency of the designed sy stem arene-Cu is comparable to that of the well-known DNA cleaving reagents such as phenanthroline-Cu and ascorbic acid-Cu. However in contrast to the mentioned reagents, the system arene-Cu does not require external reducing agents or H2O2.