Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides

Authors
Tomasi, V Laktionov, PP Bryksin, AV Volod'ko, NV Griffoni, C Rykova, EV Spisni, E Kraft, R Vlassov, VV
Citation
V. Tomasi et al., Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides, NUCLEOS NUC, 20(4-7), 2001, pp. 863-867
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
863 - 867
Database
ISI
SICI code
1525-7770(2001)20:4-7<863:GDIRFI>2.0.ZU;2-8
Abstract
Nuclear accumulation of ODNs has been associated with their binding to a se ries of nuclear proteins. These interactions could be responsible for the s equence-independent effects of ODNs as well as for their sequence-specific interactions and their intracellular distribution. Investigation of interac tion of ODNs with these proteins may shed light on the mechanisms of cellul ar uptake and nuclear accumulation of oligonucleotides.