Citation
J. Renze et al., Benzyl-functionalized cycloSal-d4T monophosphates, NUCLEOS NUC, 20(4-7), 2001, pp. 931-934
Citations number
1
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770
→ ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
931 - 934
Database
ISI
SICI code
1525-7770(2001)20:4-7<931:BCM>2.0.ZU;2-7
Abstract
Synthetic routes to benzyl-functionalized cycloSal-d4T monophosphates (7CH(
2)X-cycloSal-d4TMP) have been developed. Their hydrolytic behavior in basic
aqueous solution (pH = 7.3) was studied and their hydrolysis half-lives we
re determined. It turned out that two different degradation pathways are le
ading to different products: beside the formation of the expected d4TMP and
a styrene type derivative, a phenyl-d4T-phosphodiester was obtained as wel
l. The product distribution was specified.