Synthesis of N-2-alkylguanosine using Mitsunobu reaction as a key step

Authors
Maruyama, T Yorikane, A Kozai, S
Citation
T. Maruyama et al., Synthesis of N-2-alkylguanosine using Mitsunobu reaction as a key step, NUCLEOS NUC, 20(4-7), 2001, pp. 935-936
Citations number
5
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
935 - 936
Database
ISI
SICI code
1525-7770(2001)20:4-7<935:SONUMR>2.0.ZU;2-W
Abstract
Peracetylated guanosine was reacted with POCl3 to give an 2-acetamido-6-chl oro-9H-purine derivative, which was condensed with primary or secondary alc ohols to give N-2-alkylated analogues. The products were treated with merca ptoethanol in the presence of sodium methoxide to afford N-2-alkylguanosine s.