Pro-oligonucleotide synthesis using allyl and allyloxycarbonyl protections: Direct MALDI-TOF MS analysis on solid support

Authors
Spinelli, N Vasseur, JJ Hayakawa, Y Imbach, JL
Citation
N. Spinelli et al., Pro-oligonucleotide synthesis using allyl and allyloxycarbonyl protections: Direct MALDI-TOF MS analysis on solid support, NUCLEOS NUC, 20(4-7), 2001, pp. 947-950
Citations number
12
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
947 - 950
Database
ISI
SICI code
1525-7770(2001)20:4-7<947:PSUAAA>2.0.ZU;2-N
Abstract
The solid-support synthesis of pro-oligonucleotide heteropolymer chimeras h ad been performed with allyloxycarbonyl group (AOC) for the protection of n ucleobases and of allyl and S-acetyl-2-thioethyl (MeSATE) for phosphate pro tections to respectively generate phosphodiester and MeSATE phosphotriester linkages.