Synthesis of chimeric oligonucleotides containing internucleosidic phosphodiester and S-pivaloylthioethyl phosphotriester residues

Authors
Guzaev, AP Bhat, B Balow, G Manoharan, M
Citation
Ap. Guzaev et al., Synthesis of chimeric oligonucleotides containing internucleosidic phosphodiester and S-pivaloylthioethyl phosphotriester residues, NUCLEOS NUC, 20(4-7), 2001, pp. 1015-1018
Citations number
7
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1015 - 1018
Database
ISI
SICI code
1525-7770(2001)20:4-7<1015:SOCOCI>2.0.ZU;2-3
Abstract
Novel oligonucleotide analogs that bear phosphodiester and bioreversible S- pivaloyl 2-mercaptoethyl (SPME) phosphate triester internucleosidic linkage s are described. Their synthesis employs a novel methodology of oligonucleo tide deprotection under mild, non-aqueous conditions.