Synthesis and antiviral evaluation of C-4-hydrazide derivatives of 2 ',3 '-dideoxycytidine

Authors
Boudou-Vivet, V Mathe, C Gosselin, G
Citation
V. Boudou-vivet et al., Synthesis and antiviral evaluation of C-4-hydrazide derivatives of 2 ',3 '-dideoxycytidine, NUCLEOS NUC, 20(4-7), 2001, pp. 1029-1032
Citations number
3
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1029 - 1032
Database
ISI
SICI code
1525-7770(2001)20:4-7<1029:SAAEOC>2.0.ZU;2-2
Abstract
Syntheses of three hitherto unknown derivatives of 2',3'-dideoxycytidine, n amely C-4-(salicylic hydrazide)-ddC, C-4-(N-butyloxycarbonyl-isoleucine hyd razide)-ddC and its N-unprotected chlorhydrate salt have been carried out. These compounds do not induce inhibition of HIV-1 replication in cell cultu re experiments. Nevertheless, the modifications on the base moiety increase d in all cases the lipophilicity of the parent molecule with an acceptable water solubility compared to ddC.