Citation
S. Costanzi et al., 3 '-Deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors, NUCLEOS NUC, 20(4-7), 2001, pp. 1037-1041
Citations number
6
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770
→ ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1037 - 1041
Database
ISI
SICI code
1525-7770(2001)20:4-7<1037:3'DO1A>2.0.ZU;2-F
Abstract
2,6-Dichloro-1-deazapurine and 2,6-dichloro-3-deazapurine were coupled with
1,2-O-diacetyl-5-O-benzoyl-3-deoxy-beta -D-ribofuranose. Deprotection of t
he obtained compounds and reaction with liquid ammonia gave the desired 2-c
hloroadenine nucleosides, which were dechlorinated to afford the correspond
ing 1-deaza and 3-deazaadenosine derivatives. Biological studies performed
on ADA from calf intestine showed that these new nucleosides are inhibitors
of the enzyme.